The toothache tree, scientifically known as Zanthoxylum americanum, is a spiny tree native to the eastern United States. It has been used for centuries for its medicinal properties and as a natural remedy for toothaches and other ailments. Besides toothache tree, it is also commonly referred to as prickly ash tree or northern prickly ash. The tree's bark, roots, and fruits are all used for medicinal purposes, with the bark being the most commonly used part. Its natural pain-relieving properties have made it popular in traditional medicine, and it is still used today as a natural remedy for various ailments.