Maleficently is an adverb that means to act in a manner that is harmful or evil. Synonyms for this word include wickedly, maliciously, malevolently, and villainously. Malevolently suggests a deliberate intent to harm, while wickedly implies a sense of playful or mischievous malice. Villainously conveys a sense of evil and treachery, whereas maleficently specifically refers to causing harm. Other synonyms for maleficently include malignantly, harmfully, injuriously, and destructively. Whether you're describing a villainous character in a book or a real-life individual who is causing harm, there are plenty of words to choose from to convey the sense of maleficence.