Dentatorubral-pallidoluysian atrophy, also known as DRPLA, is a rare genetic disorder that affects the brain. DRPLA is caused by a specific mutation in the atrophin-1 gene, which leads to the loss of neurons in certain parts of the brain. Synonyms for DRPLA include Naito-Oyanagi disease, Haw River syndrome, and choreoathetosis with dementia. The symptoms of DRPLA can vary from person to person, but may include involuntary movements, seizures, dementia, and difficulty with balance and coordination. There is no cure for DRPLA, but treatment can help manage symptoms and improve quality of life.