Recombinant DNA technologies refer to genetic engineering techniques used to manipulate and recombine DNA molecules to create new genetic combinations. Synonyms for this term include gene splicing, molecular cloning, genetic engineering, and DNA recombination. Gene splicing involves cutting and joining DNA fragments from different sources to create a new DNA sequence. Molecular cloning involves the amplification of DNA fragments to create multiple copies of a particular gene or DNA sequence. Genetic engineering involves the deliberate modification of an organism's genetic makeup. DNA recombination refers to the exchange of DNA between two or more different DNA molecules to create a hybrid DNA sequence.