Synonyms for Rankle:

n.

drive someone mad, provoke, frustrate. annoy (noun)
fester, nettle, mortify, lie embedded, anger, hurt, gnaw at, pain, rile.
rankle (noun)
grate, fret, eat into.

v.

aggravate (verb)
envenom, grate, torment, harass, irk, tease, needle, vex, bother, chafe, antagonize, trouble, upset, discompose, fret, peeve, harry, badger, irritate, infuriate, annoy, inflame, disturb, hassle, nag, perturb, exacerbate, aggravate, arouse, pester, bait, bedevil, exasperate, enrage.
annoy, irritate (verb)
mortify, fret, inflame, pester, nettle, hurt, harass, fester, exasperate, pain, aggravate, chafe, irk, vex, rile, torment, anger, bother.

Other synonyms:

fester. poison
envenom.
Other relevant words:
rile, nettle, hurt, anger, pain, provoke, frustrate, fester, mortify, eat into.