Synonyms for Out-and-out:

adj.

absolute (adjective)
unmitigated, crashing.
all (adjective)
absolute, downright, rank, right-down, sheer.
all-encompassing (adjective)
thorough.
complete (adjective)
absolute, arrant, consummate, downright, outright, perfect, thorough, thoroughgoing, total, unmitigated, unqualified, utter.
dead (adjective)
entire.
flagrant (adjective)
arrant.
perfect (adjective)
perfect.
positive (adjective)
positive.

n.

adaptive, addictive, babyish, born, classy, constitutionally, flawed, flexible, Clingy, badass. all-out, arrant, big, blooming, consummate, crashing, damned, dead, flat, flat out, limited, outright, perfect, plain, positive, pure, thorough, thoroughgoing, total, unbounded, unequivocal, unlimited, unmitigated, unqualified, unrelieved, unreserved, utter. out-and-out (noun)
absolute, complete, downright, rank, right-down, sheer.

v.

complete (verb)
thorough.

Other synonyms:

arrant, crashing, unrelieved. thoroughgoing. all-out, consummate, flat out, pure, unbounded, unlimited. blooming, unequivocal. damned, unqualified. positive, unreserved. complete, dead, perfect. flat. downright
downright, outright.
Other relevant words:
adaptive, addictive, all-out, arrant, babyish, big, blooming, born, classy, completely, constitutionally, consummate, crashing, damned, dead, entire, flat, flat out, flawed, flexible, limited, outright, perfect, plain, positive, pure, thorough, thoroughgoing, total, unbounded, unequivocal, unlimited, unmitigated, unqualified, unrelieved, unreserved, utter, Clingy, badass.