Synonyms for Irritate:

n.

madden, drive someone mad. allergen, allergic, allergy, anaphylactic shock, anaphylaxis, antigen, burn, erupt, hypersensitive, intolerance, intolerant, itch, redden, swell, hypoallergenic. bug, feelings, ruffle. help. irritate (noun)
annoy, bother, chafe, get at, get to, gravel, nark, nettle, rag, rile, vex.

v.

aggravate (verb)
antagonize, arouse, badger, bait, bedevil, discompose, enrage, envenom, exacerbate, exasperate, harry, infuriate, nag, needle, peeve, perturb, pester, rankle, trouble, upset.
chafe (verb)
abrade, aggravate, chafe, disturb, fret, grate, grind, harass, rasp, resist, rub, scrape, scrub, wear.
displease (verb)
aggrieve, anger, disappoint, disgust, displease, jar, offend, provoke, repel, rile, scandalize, shock.
hurt, chafe (verb)
erupt, itch, redden, rub, sting, swell.
irritate (verb)
acerbate, annoy, bother, hassle, irk, pique, tease, vex.
pain (verb)
ache, afflict, agonize, anguish, cramp, crick, discomfort, distress, hurt, inflame, pain, rack, smart, sore, sting, stitch, suffer, throb, throe, torment, torture, wrench.
upset, anger (verb)
abrade, aggravate, annoy, bother, bug, burn, chafe, disturb, enrage, exasperate, fret, grate, harass, inflame, infuriate, irk, madden, needle, nettle, offend, pain, peeve, pester, pique, provoke, rankle, rasp, rile, ruffle, vex.

Other synonyms:

madden. ruffle. bug. burn. aggravate
get to, grate.
needle
bait.
Other relevant words:
allergen, allergic, allergy, anaphylaxis, antigen, bug, burn, erupt, feelings, get at, get to, gravel, hypersensitive, intolerance, intolerant, itch, madden, nark, nettle, rag, redden, ruffle, swell, hypoallergenic.

Usage examples for irritate

  1. The bishop without answering me referred me to his chancellor, to whom I repeated all I had said to the bishop, but with words calculated to irritate rather than to soften, and certainly not likely to obtain the release of the captain. – The Memoires of Casanova, Complete The Rare Unabridged London Edition Of 1894, plus An Unpublished Chapter of History, By Arthur Symons by Jacques Casanova de Seingalt
  2. Carrington could see that she thought it unworthy of him, and he knew that it would irritate her. – Democracy An American Novel by Henry Adams
  3. She had put him beneath further notice, and yet every toss of her head, every movement of her hands, seemed meant for him, to irritate him. – A Cumberland Vendetta by John Fox, Jr.