There are a variety of synonyms that can be used for the phrase "in a spiritual manner piously". Some potential options include devoutly, reverently, holily, religiously, sacredly, and honestly. Each of these terms emphasizes a different aspect of spirituality and religious devotion, ranging from simple respect and honor to a deeper sense of religiosity and faith. Depending on the context and the writer's intended tone, any of these synonyms could be selectively employed to enhance the meaning and impact of the text. Ultimately, the choice of synonyms will depend on the specific message being conveyed and the goals of the writer.