The phrase "enough to drive one mad" is used when something is extremely frustrating or irritating. There are plenty of synonyms that can be used to convey this sentiment, such as "exasperating," "maddening," "irksome," "exasperating," "infuriating," "exasperating," "aggravating," "annoying," "irritating," "bothersome," "vexing," "provoking," "testing," "nagging," "troublesome," "trying," "tiresome," or "wearisome." These different synonyms describe the same frustrating experience with slightly different nuances. Regardless of the exact word used, these terms all depict a situation that is sure to test one's patience and sanity.