Synonyms for Despair:

n.

say/wave/kiss goodbye to something, lose heart, wobble, break, give up on, lose/give up hope, sink, darken. dejection (noun)
contemplativeness, grimness, ennui, woefulness, sadness, plaintiveness, mournfulness, sullenness, wistfulness, moodiness, dreariness, anxiety, pensiveness, joylessness, blues, dolorousness.
depression, hopelessness (noun)
misery, despondency, discouragement, anguish, melancholy, forlornness, desperation, gloom, disheartenment, dejection.
desolation (noun)
gloominess.
despair (noun)
desperation.
hopelessness (noun)
cheerlessness, disheartenment, depression, anguish, gloominess, despondency, dispiritedness, pessimism, abandonment, downheartedness, dejection, forlornness, heartlessness, defeatism, bleakness, hopelessness, glumness, moroseness, misery, desperation, melancholy, discouragement, spiritlessness, negativity.
state (noun)
desperation.

v.

give up hope (verb)
lose heart, despond.

Other synonyms:

give up on, despond. gloom, darken. wobble. sink. break. Other relevant words:
darken, wobble, defeatism, give up, sink, despond, lose heart, gloom, break.

Usage examples for despair

  1. That my despair may not trouble you? – The Saint by Antonio Fogazzaro Commentator: William Roscoe Thayer
  2. Tony gave a gesture of despair – A Poor Man's House by Stephen Sydney Reynolds